Trained in Venice, Muziano came to Rome around 1550 and created many important landscape decorations in inaccessible villas and ecclesiastical buildings. His fame was thus dependent on the ten engravings that Cort made after his work, which were very popular and influential. Muziano frequently depicted Saint Francis, the thirteenth-century saint, withdrawn in a forest on Mount Alvernia, receiving the stigmata, or identical wounds, from a vision of Christ on the cross.